Microtubule and microtubule associated protein anomalies in psychiatric disease
نویسندگان
چکیده
منابع مشابه
Echinoderm microtubule-associated protein -like protein 5 in anterior temporal neocortex of patients with intractable epilepsy
Objective(s):EMAP-like Protein 5 (EML5) is a new echinoderm microtubule-associated protein that is expressed in the central nervous system. The aim of this study was to investigate the expression profile of EML5 in the anterior temporal neocortex of patients presenting with intractable epilepsy (IE). Materials and Methods:Western blot assays were performed to determine EML5 expression in 36 su...
متن کاملMicrotubule-associated protein 1B
Myelin-associated glycoprotein (MAG) is expressed in periaxonal membranes of myelinating glia where it is believed to function in glia-axon interactions by binding to a component of the axolemma. Experiments involving Western blot overlay and coimmunoprecipitation demonstrated that MAG binds to a phosphorylated neuronal isoform of microtubule-associated protein 1B (MAP1B) expressed in dorsal ro...
متن کاملMicrotubule-associated protein 1B
Giant axonal neuropathy (GAN), an autosomal recessive disorder caused by mutations in GAN, is characterized cytopathologically by cytoskeletal abnormality. Based on its sequence, gigaxonin contains an NH2-terminal BTB domain followed by six kelch repeats, which are believed to be important for protein-protein interactions (Adams, J., R. Kelso, and L. Cooley. 2000. Trends Cell Biol. 10:17-24.). ...
متن کاملechinoderm microtubule-associated protein -like protein 5 in anterior temporal neocortex of patients with intractable epilepsy
objective(s):emap-like protein 5 (eml5) is a new echinoderm microtubule-associated protein that is expressed in the central nervous system. the aim of this study was to investigate the expression profile of eml5 in the anterior temporal neocortex of patients presenting with intractable epilepsy (ie). materials and methods:western blot assays were performed to determine eml5 expression in 36 sur...
متن کاملDynamin: a microtubule-associated GTP-binding protein.
We recently identified dynamin as a third nucleotide-sensitive microtubule-associated protein in brain tissue, in addition to kinesin and cytoplasmic dynein. Molecular cloning analysis has revealed that dynamin contains the three consensus elements characteristic of GTP-binding proteins, and biochemical results support a role for GTP in dynamin function. Dynamin is also homologous to the Mx pro...
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ژورنال
عنوان ژورنال: Cytoskeleton
سال: 2016
ISSN: 1949-3584
DOI: 10.1002/cm.21300